Inter Milan missed a chance to move top of Serie A on Wednesday with a 2-1 defeat at Sampdoria which ended their eight-match winning streak.

Alexis Sanchez missed an early penalty for Antonio Conte's side who were tripped up by goals from former Inter players Antonio Candreva and Keita Balde.

Second-placed Inter stay one point behind Serie A leaders AC Milan who host champions Juventus later on Wednesday.

"I'm sorry because I think we deserved something more. Lady luck was not on our side today," said Conte after their second league defeat this season after Milan last October.

"It was a bit of a strange match. We found ourselves going from the missed penalty to conceding two goals which clearly created difficulties for us."

Inter's leading scorer Romelu Lukaku started on the bench as the forward recovers from a muscular problem.

Sanchez started in the Belgian's place but missed the chance to give the visitors an early advantage with Emil Audero saving a penalty.

But Candreva made no mistake from the spot after 22 minutes, sending Samir Handanovic the wrong way after Samp were awarded a penalty for a Nicolo Barella handball.

Keita Balde added a second after 38 minutes following good work from Mikkel Damsgaard, the Danish winger sending the Senegalese forward through to coolly finish.

Lukaku came off the bench in place of Roberto Gagliardini with just over an hour gone, two minutes before Stefan de Vrij's header from a Marcelo Brozovic corner reduced the deficit for the visitors.

Out-of-favour Danish midfielder Christian Eriksen, touted for a move away from Inter, was also brought on for the final 20 minutes in place of Sanchez, with Arturo Vidal coming on late for Barella, having been benched following a woeful performance last weekend.

"I always try to exploit the players according to the situations that arise," added Conte.

Sampdoria, who had lost their last two games, are 11th, and coach Claudio Ranieri hailed "a very important victory".

"We lost in Rome and didn't want to lose again," he said.

"Inter are a great team, the absence of Lukaku gave us an advantage, because with such a player in front of us we would have suffered more."

Third-placed Roma closed the gap on Inter to three points, before the two teams meet next weekend, after scoring three goals in 35 first half minutes in their 3-1 win at bottom side Crotone.

Borja Mayoral bagged a first-half brace with Henrikh Mkhitaryan adding a third from the penalty spot.

Sassuolo beat Genoa 2-1 to move fourth ahead of Napoli who fell to a shock defeat by the same scoreline to 10-man Spezia, for their first loss in their newly-named Diego Armando Maradona Stadium.

Gennaro Gattuso's side drop to fifth in a game they had dominated in the first half but proved wasteful on front of goal, starting with captain Lorenzo Insigne after just one minute in Naples.

Andrea Petagna came off the bench in the second half and put the hosts ahead just before the hour but ten minutes later M'Bala Nzola pulled the north-eastern side level from the penalty spot.

Spezia played a man down after defender Ardian Ismajli was harshly sent off for a second yellow card on 77 minutes, but substitute Tommaso Pobega grabbed the winner four minutes later.

The Serie A newcomers move out of the drop zone into 16th place after their third top-flight win.

Atalanta are back in the European places with a 3-0 win over Parma, who drop into the relegation zone.

Josip Ilicic set up Luis Muriel for Atalanta's first goal in the 15th minute in Bergamo with fellow Colombian Duvan Zapata adding a second shortly after the break and Robin Gosens wrapping up the scoring after an hour.

Lazio got back winning 2-1 against Fiorentina to move eighth, two points behind Juventus, who will start their clash at the San Siro in seventh, 10 points off league leaders Milan.