| 2. Round | 12/09/2021 | Delfino Pescara [Youth] | - | Empoli FC [Youth] | 0:0 | ||||
| 3. Round | 18/09/2021 | Empoli FC [Youth] | - | SPAL 2013 Ferrara [Youth] | 6:0 | ||||
| 5. Round | 16/10/2021 | Empoli FC [Youth] | - | Inter [Youth] | 1:1 | ||||
| 6. Round | 24/10/2021 | AS Roma [Youth] | - | Empoli FC [Youth] | 2:2 | ||||
| 11. Round | 05/12/2021 | Empoli FC [Youth] | - | Atalanta [Youth] | 1:1 | ||||
| 12. Round | 13/12/2021 | Bologna FC [Youth] | - | Empoli FC [Youth] | 3:0 | ||||
| 14. Round | 21/12/2021 | Empoli FC [Youth] | - | Sassuolo Calcio [Youth] | 0:2 | ||||
| 15. Round | 29/01/2022 | AC Milan [Youth] | - | Empoli FC [Youth] | 3:1 | ||||
| 16. Round | 01/02/2022 | Empoli FC [Youth] | - | Genoa CFC [Youth] | 0:1 | ||||
| 17. Round | 04/02/2022 | Cagliari Calcio [Youth] | - | Empoli FC [Youth] | 2:0 |
Italy