| 1. Round | 27/08/2021 | SPAL 2013 Ferrara [Youth] | - | Sampdoria [Youth] | 1:0 | ||||
| 2. Round | 13/09/2021 | SPAL 2013 Ferrara [Youth] | - | Hellas Verona [Youth] | 0:0 | ||||
| 4. Round | 26/09/2021 | SPAL 2013 Ferrara [Youth] | - | Cagliari Calcio [Youth] | 1:1 | ||||
| 7. Round | 01/11/2021 | Delfino Pescara [Youth] | - | SPAL 2013 Ferrara [Youth] | 0:1 | ||||
| 8. Round | 07/11/2021 | SPAL 2013 Ferrara [Youth] | - | Torino FC [Youth] | 0:2 | ||||
| 9. Round | 21/11/2021 | US Lecce [Youth] | - | SPAL 2013 Ferrara [Youth] | 1:5 |  |
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| 10. Round | 27/11/2021 | SPAL 2013 Ferrara [Youth] | - | Sassuolo Calcio [Youth] | 0:5 | ||||
| 11. Round | 04/12/2021 | AC Milan [Youth] | - | SPAL 2013 Ferrara [Youth] | 4:1 |  |
Italy