| 1. Round | 01/12/2021 | CFI Alicante | - | Real Betis | 0:4 | ||||
| 2. Round | 16/12/2021 | CF Talavera | - | Real Betis | 2:4 aet | ||||
| 3. Round | 05/01/2022 | Real Valladolid | - | Real Betis | 0:3 | ||||
| Round of 16 | 16/01/2022 | Real Betis | - | Sevilla FC | 2:1 |  |
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| Quarter-finals | 03/02/2022 | Real Sociedad | - | Real Betis | 0:4 | ||||
| Semi-finals | 09/02/2022 | Rayo Vallecano | - | Real Betis | 1:2 | ||||
| Semi-finals | 03/03/2022 | Real Betis | - | Rayo Vallecano | 1:1 | ||||
| Final | 23/04/2022 | Real Betis | - | Valencia CF | 5:4 pso |
Spain