| 3. Round | 31/08/2022 | FC Twente | - | SBV Excelsior | 4:0 | ||||
| 9. Round | 09/10/2022 | Feyenoord | - | FC Twente | 2:0 | ||||
| 11. Round | 23/10/2022 | SC Cambuur | - | FC Twente | 0:1 | ||||
| 13. Round | 06/11/2022 | FC Twente | - | Go Ahead Eagles | 1:1 | ||||
| 14. Round | 11/11/2022 | Sparta Rotterdam | - | FC Twente | 1:1 | ||||
| 17. Round | 22/01/2023 | FC Twente | - | FC Utrecht | 2:0 |  |
|||
| 21. Round | 12/02/2023 | FC Twente | - | FC Volendam | 3:0 | ||||
| 22. Round | 19/02/2023 | Go Ahead Eagles | - | FC Twente | 2:0 | ||||
| 23. Round | 26/02/2023 | PSV Eindhoven | - | FC Twente | 3:1 | ||||
| 24. Round | 04/03/2023 | FC Twente | - | sc Heerenveen | 3:3 | ||||
| 25. Round | 11/03/2023 | Fortuna Sittard | - | FC Twente | 0:3 | ||||
| 26. Round | 19/03/2023 | FC Twente | - | AZ Alkmaar | 2:1 | ||||
| 27. Round | 01/04/2023 | SBV Excelsior | - | FC Twente | 0:0 | ||||
| 34. Round | 28/05/2023 | FC Twente | - | AFC Ajax | 3:1 |
Netherlands
Morocco