| 3. Round | 13/09/2021 | US Triestina | - | Piacenza Calcio | 2:2 | ||||
| 7. Round | 03/10/2021 | US Triestina | - | UC AlbinoLeffe | 2:3 |  |
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| 8. Round | 10/10/2021 | Virtus Verona | - | US Triestina | 0:0 | ||||
| 14. Round | 14/11/2021 | US Triestina | - | Trento Calcio 1921 | 1:1 | ||||
| 15. Round | 22/11/2021 | FC Legnago Salus | - | US Triestina | 0:2 | ||||
| 16. Round | 28/11/2021 | US Triestina | - | Aurora Pro Patria | 1:1 | ||||
| 17. Round | 05/12/2021 | Pro Vercelli | - | US Triestina | 1:2 | |
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| 19. Round | 26/01/2022 | FC Südtirol | - | US Triestina | 1:0 | ||||
| 24. Round | 29/01/2022 | Calcio Lecco 1912 | - | US Triestina | 2:0 | ||||
| 26. Round | 12/02/2022 | UC AlbinoLeffe | - | US Triestina | 1:1 | ||||
| 27. Round | 16/02/2022 | US Triestina | - | Virtus Verona | 2:1 | ||||
| 28. Round | 20/02/2022 | US Fiorenzuola | - | US Triestina | 0:1 |  |
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| 31. Round | 14/03/2022 | Feralpisalò | - | US Triestina | 3:0 |
Portugal