| 1. Round | 12/09/2015 | US Palermo [Youth] | - | SSC Napoli [Youth] | 1:1 |  |
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| 2. Round | 19/09/2015 | Lazio Roma [Youth] | - | US Palermo [Youth] | 0:0 | ||||
| 7. Round | 14/11/2015 | FC Crotone [Youth] | - | US Palermo [Youth] | 3:4 | |
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| 9. Round | 21/11/2015 | US Avellino [Youth] | - | US Palermo [Youth] | 0:3 | |
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| 10. Round | 28/11/2015 | US Palermo [Youth] | - | Virtus Lanciano [Youth] | 1:2 | ||||
| 14. Round | 16/01/2016 | SSC Napoli [Youth] | - | US Palermo [Youth] | 1:2 | |
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| 15. Round | 23/01/2016 | US Palermo [Youth] | - | Lazio Roma [Youth] | 2:1 | ||||
| 16. Round | 30/01/2016 | US Palermo [Youth] | - | Delfino Pescara [Youth] | 2:0 | |
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| 18. Round | 13/02/2016 | US Palermo [Youth] | - | Frosinone Calcio [Youth] | 1:0 | |
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| 19. Round | 20/02/2016 | Latina Calcio [Youth] | - | US Palermo [Youth] | 1:4 | |
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| 20. Round | 27/02/2016 | US Palermo [Youth] | - | FC Crotone [Youth] | 1:0 | ||||
| 21. Round | 04/03/2016 | AS Roma [Youth] | - | US Palermo [Youth] | 1:0 | ||||
| 22. Round | 09/03/2016 | US Palermo [Youth] | - | US Avellino [Youth] | 5:0 | |
Italy