| 17. Round | 25/01/1959 | AC Milan | - | Bologna FC | 4:3 | ||||
| 18. Round | 01/02/1959 | Bologna FC | - | AS Bari | 1:1 | ||||
| 19. Round | 08/02/1959 | Genoa CFC | - | Bologna FC | 1:0 | ||||
| 20. Round | 15/02/1959 | Bologna FC | - | Udinese Calcio | 2:0 | ||||
| 21. Round | 22/02/1959 | AS Roma | - | Bologna FC | 0:1 | ||||
| 22. Round | 08/03/1959 | Bologna FC | - | Calcio Padova | 2:0 | ||||
| 23. Round | 15/03/1959 | SPAL Ferrara | - | Bologna FC | 0:1 | ||||
| 24. Round | 22/03/1959 | Bologna FC | - | Torino FC | 0:0 | ||||
| 25. Round | 29/03/1959 | US Triestina | - | Bologna FC | 3:2 | ||||
| 26. Round | 05/04/1959 | Bologna FC | - | ACF Fiorentina | 0:4 | ||||
| 27. Round | 12/04/1959 | Inter | - | Bologna FC | 5:1 | ||||
| 28. Round | 19/04/1959 | Bologna FC | - | AC Lanerossi Vicenza | 1:0 | ||||
| 29. Round | 26/04/1959 | Bologna FC | - | Lazio Roma | 1:1 | ||||
| 30. Round | 17/05/1959 | SSC Napoli | - | Bologna FC | 4:2 | ||||
| 31. Round | 24/05/1959 | Bologna FC | - | Juventus | 4:1 | ||||
| 32. Round | 28/05/1959 | US Alessandria 1912 | - | Bologna FC | 1:0 | ||||
| 33. Round | 31/05/1959 | Sampdoria | - | Bologna FC | 2:1 |
Italy