| 1. Round | 19/09/1948 | Genoa CFC | - | Calcio Padova | 7:1 |  |
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| 2. Round | 26/09/1948 | US Livorno | - | Genoa CFC | 2:2 | ||||
| 3. Round | 03/10/1948 | Genoa CFC | - | Juventus | 2:1 | ||||
| 4. Round | 10/10/1948 | Bologna FC | - | Genoa CFC | 2:2 | ||||
| 5. Round | 17/10/1948 | Sampdoria | - | Genoa CFC | 5:1 | ||||
| 6. Round | 24/10/1948 | Genoa CFC | - | Inter | 4:1 | |
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| 7. Round | 31/10/1948 | AS Roma | - | Genoa CFC | 1:0 | ||||
| 8. Round | 04/11/1948 | Genoa CFC | - | US Palermo | 1:1 | ||||
| 9. Round | 07/11/1948 | AS Bari | - | Genoa CFC | 0:0 | ||||
| 11. Round | 21/11/1948 | Genoa CFC | - | Atalanta | 2:0 | ||||
| 12. Round | 28/11/1948 | Lucchese | - | Genoa CFC | 0:0 | ||||
| 14. Round | 08/12/1948 | Genoa CFC | - | AC Milan | 1:0 | ||||
| 15. Round | 12/12/1948 | Genoa CFC | - | ACF Fiorentina | 4:2 | ||||
| 16. Round | 19/12/1948 | Novara Calcio | - | Genoa CFC | 1:2 | ||||
| 17. Round | 26/12/1948 | Genoa CFC | - | Torino FC | 3:0 | |
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| 18. Round | 02/01/1949 | Genoa CFC | - | Modena FC | 1:0 | ||||
| 19. Round | 05/01/1949 | Aurora Pro Patria | - | Genoa CFC | 2:1 | ||||
| 28. Round | 13/03/1949 | Genoa CFC | - | AS Bari | 2:1 | ||||
| 29. Round | 20/03/1949 | Lazio Roma | - | Genoa CFC | 5:1 | |
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| 30. Round | 03/04/1949 | Atalanta | - | Genoa CFC | 0:0 | ||||
| 31. Round | 10/04/1949 | Genoa CFC | - | Lucchese | 0:0 |  |
Italy