| 1. Round | 28/08/2021 | FC Legnago Salus | - | Mantova 1911 SSD | 1:1 | ||||
| 2. Round | 04/09/2021 | Mantova 1911 SSD | - | Giana Erminio | 1:1 | ||||
| 4. Round | 19/09/2021 | UC AlbinoLeffe | - | Mantova 1911 SSD | 1:0 | ||||
| 5. Round | 26/09/2021 | Mantova 1911 SSD | - | Piacenza Calcio | 2:1 | ||||
| 6. Round | 29/09/2021 | Trento Calcio 1921 | - | Mantova 1911 SSD | 2:2 | ||||
| 7. Round | 03/10/2021 | Mantova 1911 SSD | - | Juventus II | 0:1 | ||||
| 8. Round | 10/10/2021 | Seregno | - | Mantova 1911 SSD | 1:1 | ||||
| 9. Round | 17/10/2021 | Mantova 1911 SSD | - | Calcio Lecco 1912 | 1:1 | ||||
| 10. Round | 20/10/2021 | US Triestina | - | Mantova 1911 SSD | 2:1 | ||||
| 11. Round | 24/10/2021 | Mantova 1911 SSD | - | FC Südtirol | 0:1 | ||||
| 12. Round | 31/10/2021 | US Fiorenzuola | - | Mantova 1911 SSD | 0:0 | ||||
| 15. Round | 21/11/2021 | Virtus Verona | - | Mantova 1911 SSD | 1:0 | ||||
| 18. Round | 11/12/2021 | Mantova 1911 SSD | - | Aurora Pro Patria | 0:0 | ||||
| 19. Round | 18/12/2021 | Pro Vercelli | - | Mantova 1911 SSD | 1:1 | ||||
| 23. Round | 23/01/2022 | Mantova 1911 SSD | - | UC AlbinoLeffe | 1:1 |
Italy