| Group A | 14/09/2017 | Villarreal CF | - | FK Astana | 3:1 | ||||
| Group A | 28/09/2017 | Maccabi Tel Aviv | - | Villarreal CF | 0:0 | ||||
| Group A | 19/10/2017 | Villarreal CF | - | Slavia Praha | 2:2 | ||||
| Group A | 23/11/2017 | FK Astana | - | Villarreal CF | 2:3 | ||||
| Round of 32 | 22/02/2018 | Villarreal CF | - | Olympique Lyonnais | 0:1 |
Italy
