| 7. Round | 22/01/2021 | Ascoli Calcio [Youth] | - | Sampdoria [Youth] | 1:3 |  |
|||
| 4. Round | 26/01/2021 | Sampdoria [Youth] | - | Empoli FC [Youth] | 4:1 | |
|||
| 12. Round | 28/02/2021 | Sampdoria [Youth] | - | AS Roma [Youth] | 1:1 | ||||
| 17. Round | 03/04/2021 | Lazio Roma [Youth] | - | Sampdoria [Youth] | 1:4 | ||||
| 21. Round | 01/05/2021 | SPAL 2013 Ferrara [Youth] | - | Sampdoria [Youth] | 2:1 | ||||
| 22. Round | 08/05/2021 | Sampdoria [Youth] | - | Ascoli Calcio [Youth] | 6:1 | ||||
| 25. Round | 26/05/2021 | Sampdoria [Youth] | - | Sassuolo Calcio [Youth] | 1:1 | ||||
| 26. Round | 29/05/2021 | AC Milan [Youth] | - | Sampdoria [Youth] | 0:2 | ||||
| 27. Round | 06/06/2021 | AS Roma [Youth] | - | Sampdoria [Youth] | 2:2 | ||||
| 28. Round | 09/06/2021 | Sampdoria [Youth] | - | Cagliari Calcio [Youth] | 1:0 | ||||
| 29. Round | 12/06/2021 | ACF Fiorentina [Youth] | - | Sampdoria [Youth] | 1:1 | ||||
| 30. Round | 16/06/2021 | Sampdoria [Youth] | - | Torino FC [Youth] | 5:0 | |
Italy