| 1. Round | 14/08/2021 | AFC Ajax | - | NEC Nijmegen | 5:0 | ||||
| 2. Round | 22/08/2021 | FC Twente | - | AFC Ajax | 1:1 | ||||
| 3. Round | 29/08/2021 | AFC Ajax | - | Vitesse | 5:0 | ||||
| 4. Round | 11/09/2021 | PEC Zwolle | - | AFC Ajax | 0:2 | ||||
| 5. Round | 18/09/2021 | AFC Ajax | - | SC Cambuur | 9:0 |  |
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| 7. Round | 25/09/2021 | AFC Ajax | - | FC Groningen | 3:0 | ||||
| 8. Round | 03/10/2021 | AFC Ajax | - | FC Utrecht | 0:1 | ||||
| 9. Round | 16/10/2021 | sc Heerenveen | - | AFC Ajax | 0:2 | |
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| 10. Round | 24/10/2021 | AFC Ajax | - | PSV Eindhoven | 5:0 | ||||
| 11. Round | 30/10/2021 | Heracles Almelo | - | AFC Ajax | 0:0 | ||||
| 12. Round | 07/11/2021 | AFC Ajax | - | Go Ahead Eagles | 0:0 | ||||
| 13. Round | 21/11/2021 | RKC Waalwijk | - | AFC Ajax | 0:5 | ||||
| 14. Round | 28/11/2021 | Sparta Rotterdam | - | AFC Ajax | 0:1 |  |
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| 15. Round | 02/12/2021 | AFC Ajax | - | Willem II | 5:0 | ||||
| 18. Round | 22/12/2021 | AFC Ajax | - | Fortuna Sittard | 5:0 |
Brazil
