| 4. Round | 02/10/2021 | Virtus Entella [Youth] | - | Udinese Calcio [Youth] | 1:1 | ||||
| 7. Round | 30/10/2021 | Virtus Entella [Youth] | - | AC Monza [Youth] | 1:2 | ||||
| 9. Round | 20/11/2021 | Virtus Entella [Youth] | - | Como 1907 [Youth] | 3:0 | ||||
| 10. Round | 27/11/2021 | US Alessandria 1912 [Youth] | - | Virtus Entella [Youth] | 1:3 | ||||
| 11. Round | 04/12/2021 | Virtus Entella [Youth] | - | Pordenone Calcio [Youth] | 1:0 | ||||
| 12. Round | 11/12/2021 | Virtus Entella [Youth] | - | AS Cittadella [Youth] | 2:2 | ||||
| 13. Round | 18/12/2021 | Parma Calcio 1913 [Youth] | - | Virtus Entella [Youth] | 4:1 | ||||
| 15. Round | 05/02/2022 | Venezia FC [Youth] | - | Virtus Entella [Youth] | 3:0 | ||||
| 20. Round | 12/03/2022 | AC Monza [Youth] | - | Virtus Entella [Youth] | 3:2 |  |
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| 22. Round | 26/03/2022 | Como 1907 [Youth] | - | Virtus Entella [Youth] | 2:2 | |
Italy