| 3. Round | 12/09/2021 | Feralpisalò | - | Mantova 1911 SSD | 1:1 | ||||
| 4. Round | 19/09/2021 | UC AlbinoLeffe | - | Mantova 1911 SSD | 1:0 | ||||
| 5. Round | 26/09/2021 | Mantova 1911 SSD | - | Piacenza Calcio | 2:1 |  |
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| 17. Round | 04/12/2021 | US Pergolettese | - | Mantova 1911 SSD | 1:1 | ||||
| 19. Round | 18/12/2021 | Pro Vercelli | - | Mantova 1911 SSD | 1:1 | ||||
| 24. Round | 29/01/2022 | Piacenza Calcio | - | Mantova 1911 SSD | 1:0 | ||||
| 27. Round | 16/02/2022 | Mantova 1911 SSD | - | Seregno | 3:1 | |
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| 28. Round | 20/02/2022 | Calcio Lecco 1912 | - | Mantova 1911 SSD | 2:0 | ||||
| 22. Round | 23/02/2022 | Mantova 1911 SSD | - | Feralpisalò | 2:1 | ||||
| 30. Round | 06/03/2022 | FC Südtirol | - | Mantova 1911 SSD | 1:0 | ||||
| 32. Round | 16/03/2022 | Calcio Padova | - | Mantova 1911 SSD | 1:0 | ||||
| 34. Round | 26/03/2022 | Mantova 1911 SSD | - | Virtus Verona | 2:2 | ||||
| 35. Round | 02/04/2022 | AC Renate | - | Mantova 1911 SSD | 3:1 | ||||
| 36. Round | 10/04/2022 | Mantova 1911 SSD | - | US Pergolettese | 0:2 | ||||
| 37. Round | 16/04/2022 | Aurora Pro Patria | - | Mantova 1911 SSD | 2:1 |
Italy