| 1. Round | 01/09/2016 | Montevideo Wanderers | - | River Plate | 1:1 | ||||
| 2. Round | 04/09/2016 | CA Cerro | - | Montevideo Wanderers | 1:3 |  |
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| 3. Round | 10/09/2016 | Peñarol | - | Montevideo Wanderers | 0:1 | ||||
| 4. Round | 17/09/2016 | Racing | - | Montevideo Wanderers | 1:1 | ||||
| 5. Round | 24/09/2016 | Montevideo Wanderers | - | Nacional | 1:3 | |
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| 6. Round | 02/10/2016 | Defensor Sporting | - | Montevideo Wanderers | 1:1 | ||||
| 7. Round | 08/10/2016 | Montevideo Wanderers | - | Juventud de Las Piedras | 1:0 | ||||
| 8. Round | 15/10/2016 | Montevideo Wanderers | - | Boston River | 1:0 | ||||
| 9. Round | 23/10/2016 | Montevideo Wanderers | - | Sud América | 2:1 | |
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| 10. Round | 30/10/2016 | Montevideo Wanderers | - | Plaza Colonia | 0:0 | ||||
| 11. Round | 12/11/2016 | Liverpool | - | Montevideo Wanderers | 2:1 | |
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| 13. Round | 26/11/2016 | Montevideo Wanderers | - | Fénix | 4:2 |
Uruguay