| 6. Round | 23/10/2021 | Sampdoria [Youth] | - | Cagliari Calcio [Youth] | 5:3 | ||||
| 7. Round | 01/11/2021 | Torino FC [Youth] | - | Sampdoria [Youth] | 2:1 | ||||
| 9. Round | 20/11/2021 | Genoa CFC [Youth] | - | Sampdoria [Youth] | 2:4 | ||||
| 13. Round | 17/12/2021 | Sassuolo Calcio [Youth] | - | Sampdoria [Youth] | 3:2 | ||||
| 24. Round | 14/03/2022 | Sampdoria [Youth] | - | Torino FC [Youth] | 0:0 | ||||
| 25. Round | 20/03/2022 | Delfino Pescara [Youth] | - | Sampdoria [Youth] | 1:2 | ||||
| 27. Round | 10/04/2022 | Empoli FC [Youth] | - | Sampdoria [Youth] | 1:0 | ||||
| 30. Round | 20/04/2022 | Sampdoria [Youth] | - | Sassuolo Calcio [Youth] | 3:3 | ||||
| 31. Round | 25/04/2022 | Hellas Verona [Youth] | - | Sampdoria [Youth] | 4:4 |
Italy