| 19. Round | 04/02/2022 | Arsenal FC U23 | - | Chelsea FC U23 | 3:1 | ||||
| 22. Round | 11/03/2022 | Chelsea FC U23 | - | West Ham United U23 | 1:1 | ||||
| 23. Round | 20/03/2022 | Chelsea FC U23 | - | Leeds United U23 | 1:0 | ||||
| 24. Round | 02/04/2022 | Liverpool FC U23 | - | Chelsea FC U23 | 2:2 | ||||
| 15. Round | 08/04/2022 | Manchester United U23 | - | Chelsea FC U23 | 1:0 | ||||
| 21. Round | 15/04/2022 | Everton FC U23 | - | Chelsea FC U23 | 2:0 | ||||
| 25. Round | 25/04/2022 | Brighton & Hove Albion U23 | - | Chelsea FC U23 | 1:2 | ||||
| 26. Round | 01/05/2022 | Blackburn Rovers U23 | - | Chelsea FC U23 | 4:3 | ||||
| 20. Round | 08/05/2022 | Chelsea FC U23 | - | Tottenham Hotspur U23 | 2:1 |
England