| 1. Round | 11/09/2021 | L.R. Vicenza [Youth] | - | Virtus Entella [Youth] | 0:3 |  |
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| 2. Round | 18/09/2021 | Virtus Entella [Youth] | - | Venezia FC [Youth] | 1:7 | ||||
| 3. Round | 25/09/2021 | AC Reggiana 1919 [Youth] | - | Virtus Entella [Youth] | 1:2 | ||||
| 5. Round | 16/10/2021 | US Cremonese [Youth] | - | Virtus Entella [Youth] | 0:3 | |
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| 7. Round | 30/10/2021 | Virtus Entella [Youth] | - | AC Monza [Youth] | 1:2 | ||||
| 8. Round | 06/11/2021 | Brescia Calcio [Youth] | - | Virtus Entella [Youth] | 3:1 | ||||
| 9. Round | 20/11/2021 | Virtus Entella [Youth] | - | Como 1907 [Youth] | 3:0 | ||||
| 10. Round | 27/11/2021 | US Alessandria 1912 [Youth] | - | Virtus Entella [Youth] | 1:3 | ||||
| 11. Round | 04/12/2021 | Virtus Entella [Youth] | - | Pordenone Calcio [Youth] | 1:0 | ||||
| 16. Round | 12/02/2022 | Virtus Entella [Youth] | - | AC Reggiana 1919 [Youth] | 1:0 | ||||
| 17. Round | 19/02/2022 | Udinese Calcio [Youth] | - | Virtus Entella [Youth] | 1:0 | |
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| 18. Round | 26/02/2022 | Virtus Entella [Youth] | - | US Cremonese [Youth] | 0:1 | ||||
| 20. Round | 12/03/2022 | AC Monza [Youth] | - | Virtus Entella [Youth] | 3:2 | ||||
| 21. Round | 19/03/2022 | Virtus Entella [Youth] | - | Brescia Calcio [Youth] | 1:3 |
Italy