| 1. Round | 11/09/2021 | Venezia FC [Youth] | - | US Cremonese [Youth] | 0:0 | ||||
| 2. Round | 18/09/2021 | US Cremonese [Youth] | - | AC Reggiana 1919 [Youth] | 1:0 | ||||
| 3. Round | 25/09/2021 | US Cremonese [Youth] | - | US Alessandria 1912 [Youth] | 5:3 |  |
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| 4. Round | 02/10/2021 | AC Monza [Youth] | - | US Cremonese [Youth] | 3:2 | |
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| 5. Round | 16/10/2021 | US Cremonese [Youth] | - | Virtus Entella [Youth] | 0:3 | ||||
| 6. Round | 23/10/2021 | Brescia Calcio [Youth] | - | US Cremonese [Youth] | 1:1 | ||||
| 7. Round | 30/10/2021 | US Cremonese [Youth] | - | Parma Calcio 1913 [Youth] | 0:6 | ||||
| 11. Round | 26/01/2022 | Udinese Calcio [Youth] | - | US Cremonese [Youth] | 0:0 |
Italy