| 2. Round | 24/08/2018 | Almere City FC | - | Roda JC Kerkrade | 1:2 | ||||
| 5. Round | 14/09/2018 | Almere City FC | - | FC Utrecht (J) | 3:1 |  |
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| 6. Round | 21/09/2018 | FC Den Bosch | - | Almere City FC | 1:4 | |
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| 7. Round | 28/09/2018 | Almere City FC | - | RKC Waalwijk | 2:1 |  |
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| 8. Round | 05/10/2018 | Almere City FC | - | NEC Nijmegen | 1:0 | |
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| 9. Round | 12/10/2018 | FC Volendam | - | Almere City FC | 2:2 | |
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| 10. Round | 19/10/2018 | Almere City FC | - | Go Ahead Eagles | 0:1 | ||||
| 12. Round | 02/11/2018 | Helmond Sport | - | Almere City FC | 1:2 | |
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| 13. Round | 09/11/2018 | Almere City FC | - | SC Cambuur | 2:1 | |
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| 14. Round | 17/11/2018 | TOP Oss | - | Almere City FC | 2:0 | ||||
| 16. Round | 30/11/2018 | Telstar | - | Almere City FC | 1:1 | ||||
| 17. Round | 07/12/2018 | Sparta Rotterdam | - | Almere City FC | 6:1 | ||||
| 22. Round | 26/01/2019 | Almere City FC | - | FC Twente | 1:3 |
Italy