| 9. Round | 04/09/2022 | Cerro Porteño | - | Libertad | 1:0 | ||||
| 11. Round | 14/09/2022 | Libertad | - | Tacuary | 2:0 | ||||
| 12. Round | 18/09/2022 | Libertad | - | Sportivo Ameliano | 2:1 | ||||
| 14. Round | 02/10/2022 | Libertad | - | General Caballero DJLM | 1:0 | ||||
| 13. Round | 12/10/2022 | Club Olimpia | - | Libertad | 1:0 | ||||
| 17. Round | 17/10/2022 | Sol de América | - | Libertad | 1:1 | ||||
| 18. Round | 23/10/2022 | Libertad | - | Club Nacional | 0:1 |  |
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| 19. Round | 27/10/2022 | Guaraní | - | Libertad | 1:2 | ||||
| 20. Round | 31/10/2022 | Libertad | - | Cerro Porteño | 0:0 |
Paraguay