| 3. Round | 12/09/2021 | Sampdoria | - | Inter | 2:2 | ||||
| 4. Round | 19/09/2021 | Empoli FC | - | Sampdoria | 0:3 |  |
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| 5. Round | 23/09/2021 | Sampdoria | - | SSC Napoli | 0:4 | ||||
| 6. Round | 26/09/2021 | Juventus | - | Sampdoria | 3:2 | ||||
| 7. Round | 03/10/2021 | Sampdoria | - | Udinese Calcio | 3:3 | ||||
| 10. Round | 27/10/2021 | Sampdoria | - | Atalanta | 1:3 | ||||
| 12. Round | 07/11/2021 | Sampdoria | - | Bologna FC | 1:2 | ||||
| 20. Round | 06/01/2022 | Sampdoria | - | Cagliari Calcio | 1:2 | ||||
| 22. Round | 15/01/2022 | Sampdoria | - | Torino FC | 1:2 | ||||
| 23. Round | 23/01/2022 | Spezia Calcio | - | Sampdoria | 1:0 |
Italy