| Group D | 16/09/2021 | Eintracht Frankfurt | - | Fenerbahçe | 1:1 | ||||
| Group D | 21/10/2021 | Eintracht Frankfurt | - | Olympiakos Piraeus | 3:1 | ||||
| Group D | 04/11/2021 | Olympiakos Piraeus | - | Eintracht Frankfurt | 1:2 | ||||
| Group D | 25/11/2021 | Eintracht Frankfurt | - | Royal Antwerp FC | 2:2 | ||||
| Group D | 09/12/2021 | Fenerbahçe | - | Eintracht Frankfurt | 1:1 |  |
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| Round of 16 | 09/03/2022 | Real Betis | - | Eintracht Frankfurt | 1:2 | ||||
| Round of 16 | 17/03/2022 | Eintracht Frankfurt | - | Real Betis | 1:1 aet | ||||
| Quarter-finals | 07/04/2022 | Eintracht Frankfurt | - | FC Barcelona | 1:1 | ||||
| Quarter-finals | 14/04/2022 | FC Barcelona | - | Eintracht Frankfurt | 2:3 |  |
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| Semi-finals | 05/05/2022 | Eintracht Frankfurt | - | West Ham United | 1:0 | |
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| Final | 18/05/2022 | Eintracht Frankfurt | - | Rangers FC | 5:4 pso |
France
