| 4. Round | 12/10/1958 | Sampdoria | - | AC Milan | 0:0 | ||||
| 5. Round | 19/10/1958 | Udinese Calcio | - | Sampdoria | 1:1 | ||||
| 6. Round | 26/10/1958 | Sampdoria | - | ACF Fiorentina | 1:1 | ||||
| 7. Round | 02/11/1958 | SPAL Ferrara | - | Sampdoria | 1:2 | ||||
| 8. Round | 16/11/1958 | Sampdoria | - | Genoa CFC | 2:1 | ||||
| 9. Round | 23/11/1958 | Inter | - | Sampdoria | 5:1 | ||||
| 12. Round | 21/12/1958 | Juventus | - | Sampdoria | 1:0 | ||||
| 13. Round | 28/12/1958 | Sampdoria | - | US Triestina | 2:0 | ||||
| 14. Round | 04/01/1959 | AC Lanerossi Vicenza | - | Sampdoria | 1:2 | ||||
| 15. Round | 11/01/1959 | Sampdoria | - | AS Roma | 0:0 | ||||
| 16. Round | 18/01/1959 | Bologna FC | - | Sampdoria | 1:2 | ||||
| 17. Round | 25/01/1959 | US Alessandria 1912 | - | Sampdoria | 1:1 | ||||
| 18. Round | 01/02/1959 | Sampdoria | - | Lazio Roma | 1:2 | ||||
| 29. Round | 26/04/1959 | Sampdoria | - | Juventus | 3:2 | ||||
| 30. Round | 17/05/1959 | US Triestina | - | Sampdoria | 1:2 | ||||
| 31. Round | 24/05/1959 | Sampdoria | - | AC Lanerossi Vicenza | 2:0 | ||||
| 32. Round | 28/05/1959 | AS Roma | - | Sampdoria | 1:0 | ||||
| 33. Round | 31/05/1959 | Sampdoria | - | Bologna FC | 2:1 | ||||
| 34. Round | 07/06/1959 | Sampdoria | - | US Alessandria 1912 | 3:1 |
Italy