| 3. Round | 17/09/2021 | Sassuolo Calcio [Youth] | - | Genoa CFC [Youth] | 0:1 | ||||
| 6. Round | 22/10/2021 | SPAL 2013 Ferrara [Youth] | - | Genoa CFC [Youth] | 1:3 | ||||
| 7. Round | 01/11/2021 | Genoa CFC [Youth] | - | Bologna FC [Youth] | 1:2 | ||||
| 8. Round | 06/11/2021 | Juventus [Youth] | - | Genoa CFC [Youth] | 2:1 |  |
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| 9. Round | 20/11/2021 | Genoa CFC [Youth] | - | Sampdoria [Youth] | 2:4 | |
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| 10. Round | 28/11/2021 | ACF Fiorentina [Youth] | - | Genoa CFC [Youth] | 0:0 | ||||
| 11. Round | 06/12/2021 | Genoa CFC [Youth] | - | Hellas Verona [Youth] | 3:1 | ||||
| 12. Round | 11/12/2021 | Inter [Youth] | - | Genoa CFC [Youth] | 2:2 | |
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| 13. Round | 19/12/2021 | Genoa CFC [Youth] | - | Atalanta [Youth] | 2:0 | ||||
| 24. Round | 12/03/2022 | Bologna FC [Youth] | - | Genoa CFC [Youth] | 1:0 | ||||
| 19. Round | 16/03/2022 | Cagliari Calcio [Youth] | - | Genoa CFC [Youth] | 2:0 | ||||
| 25. Round | 20/03/2022 | Genoa CFC [Youth] | - | Juventus [Youth] | 1:2 | ||||
| 29. Round | 16/04/2022 | Genoa CFC [Youth] | - | Inter [Youth] | 0:4 | ||||
| 30. Round | 20/04/2022 | Atalanta [Youth] | - | Genoa CFC [Youth] | 1:0 | |
Italy