| 1. Round | 31/08/2008 | Racing Santander | - | Sevilla FC | 1:1 | ||||
| 2. Round | 13/09/2008 | Sevilla FC | - | Sporting Gijón | 4:3 | ||||
| 7. Round | 19/10/2008 | UD Almería | - | Sevilla FC | 0:1 | ||||
| 9. Round | 02/11/2008 | Real Valladolid | - | Sevilla FC | 3:2 | ||||
| 10. Round | 09/11/2008 | Sevilla FC | - | Recreativo Huelva | 1:0 | ||||
| 11. Round | 16/11/2008 | Getafe CF | - | Sevilla FC | 0:2 | ||||
| 13. Round | 29/11/2008 | Sevilla FC | - | FC Barcelona | 0:3 | ||||
| 14. Round | 07/12/2008 | Real Madrid | - | Sevilla FC | 3:4 | ||||
| 15. Round | 14/12/2008 | Sevilla FC | - | Villarreal CF | 1:0 | ||||
| 16. Round | 21/12/2008 | RCD Mallorca | - | Sevilla FC | 0:0 | ||||
| 17. Round | 04/01/2009 | Sevilla FC | - | CA Osasuna | 1:1 | ||||
| 21. Round | 01/02/2009 | Sporting Gijón | - | Sevilla FC | 1:0 | ||||
| 23. Round | 15/02/2009 | Espanyol Barcelona | - | Sevilla FC | 0:2 | ||||
| 24. Round | 21/02/2009 | Sevilla FC | - | Atlético Madrid | 1:0 |  |
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| 25. Round | 28/02/2009 | Athletic Club | - | Sevilla FC | 1:2 | ||||
| 29. Round | 04/04/2009 | Recreativo Huelva | - | Sevilla FC | 0:1 | |
Argentina
Italy 
