| 2. Round | 30/07/2021 | Górnik Zabrze | - | Lech Poznań | 1:3 | ||||
| 3. Round | 06/08/2021 | Lech Poznań | - | KS Cracovia | 2:0 | ||||
| 4. Round | 13/08/2021 | Bruk-Bet Termalica Nieciecza | - | Lech Poznań | 1:3 | ||||
| 6. Round | 28/08/2021 | Lech Poznań | - | Pogoń Szczecin | 1:1 | ||||
| 9. Round | 24/09/2021 | Jagiellonia Białystok | - | Lech Poznań | 1:0 | ||||
| 10. Round | 02/10/2021 | Lech Poznań | - | Śląsk Wrocław | 4:0 | ||||
| 14. Round | 06/11/2021 | Górnik Łęczna | - | Lech Poznań | 1:1 | ||||
| 16. Round | 28/11/2021 | Lech Poznań | - | Warta Poznań | 2:0 | ||||
| 19. Round | 19/12/2021 | Lech Poznań | - | Górnik Zabrze | 2:1 | ||||
| 20. Round | 06/02/2022 | KS Cracovia | - | Lech Poznań | 3:3 | ||||
| 23. Round | 26/02/2022 | Pogoń Szczecin | - | Lech Poznań | 0:3 | ||||
| 25. Round | 13/03/2022 | Wisła Kraków | - | Lech Poznań | 1:1 | ||||
| 26. Round | 19/03/2022 | Lech Poznań | - | Jagiellonia Białystok | 3:0 |  |
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| 27. Round | 01/04/2022 | Śląsk Wrocław | - | Lech Poznań | 0:1 | ||||
| 28. Round | 09/04/2022 | Lech Poznań | - | Legia Warszawa | 1:1 | ||||
| 29. Round | 16/04/2022 | Wisła Płock | - | Lech Poznań | 0:1 | ||||
| 31. Round | 20/04/2022 | Lech Poznań | - | Górnik Łęczna | 3:0 | ||||
| 30. Round | 24/04/2022 | Lech Poznań | - | FKS Stal Mielec | 3:1 |
Poland