| 1. Round | 20/09/2020 | Genoa CFC | - | FC Crotone | 4:1 | ||||
| 2. Round | 27/09/2020 | SSC Napoli | - | Genoa CFC | 6:0 | ||||
| 5. Round | 24/10/2020 | Genoa CFC | - | Inter | 0:2 | ||||
| 6. Round | 01/11/2020 | Sampdoria | - | Genoa CFC | 1:1 | ||||
| 12. Round | 16/12/2020 | Genoa CFC | - | AC Milan | 2:2 | ||||
| 17. Round | 09/01/2021 | Genoa CFC | - | Bologna FC | 2:0 | ||||
| 19. Round | 24/01/2021 | Genoa CFC | - | Cagliari Calcio | 1:0 | ||||
| 20. Round | 31/01/2021 | FC Crotone | - | Genoa CFC | 0:3 | ||||
| 24. Round | 28/02/2021 | Inter | - | Genoa CFC | 3:0 | ||||
| 26. Round | 07/03/2021 | AS Roma | - | Genoa CFC | 1:0 | ||||
| 29. Round | 03/04/2021 | Genoa CFC | - | ACF Fiorentina | 1:1 | ||||
| 30. Round | 11/04/2021 | Juventus | - | Genoa CFC | 3:1 | ||||
| 37. Round | 15/05/2021 | Genoa CFC | - | Atalanta | 3:4 | ||||
| 38. Round | 22/05/2021 | Cagliari Calcio | - | Genoa CFC | 0:1 |  |
Italy