| 9. Round | 21/11/2021 | US Lecce [Youth] | - | SPAL 2013 Ferrara [Youth] | 1:5 | ||||
| 12. Round | 10/12/2021 | AS Roma [Youth] | - | SPAL 2013 Ferrara [Youth] | 4:1 | ||||
| 14. Round | 22/12/2021 | Atalanta [Youth] | - | SPAL 2013 Ferrara [Youth] | 3:0 | ||||
| 15. Round | 29/01/2022 | SPAL 2013 Ferrara [Youth] | - | Inter [Youth] | 0:2 |  |
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| 16. Round | 02/02/2022 | SSC Napoli [Youth] | - | SPAL 2013 Ferrara [Youth] | 4:2 | ||||
| 22. Round | 05/03/2022 | SPAL 2013 Ferrara [Youth] | - | Bologna FC [Youth] | 2:2 | ||||
| 23. Round | 09/03/2022 | Genoa CFC [Youth] | - | SPAL 2013 Ferrara [Youth] | 1:1 |  |
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| 24. Round | 13/03/2022 | SPAL 2013 Ferrara [Youth] | - | Delfino Pescara [Youth] | 1:2 | |
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| 26. Round | 03/04/2022 | SPAL 2013 Ferrara [Youth] | - | US Lecce [Youth] | 2:0 | |
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| 27. Round | 09/04/2022 | Sassuolo Calcio [Youth] | - | SPAL 2013 Ferrara [Youth] | 5:2 | |
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| 28. Round | 12/04/2022 | SPAL 2013 Ferrara [Youth] | - | AC Milan [Youth] | 0:4 | ||||
| 32. Round | 29/04/2022 | Inter [Youth] | - | SPAL 2013 Ferrara [Youth] | 3:1 |
Italy