| 3. Round | 18/09/2021 | Empoli FC [Youth] | - | SPAL 2013 Ferrara [Youth] | 6:0 | ||||
| 8. Round | 07/11/2021 | SPAL 2013 Ferrara [Youth] | - | Torino FC [Youth] | 0:2 | ||||
| 9. Round | 21/11/2021 | US Lecce [Youth] | - | SPAL 2013 Ferrara [Youth] | 1:5 | ||||
| 10. Round | 27/11/2021 | SPAL 2013 Ferrara [Youth] | - | Sassuolo Calcio [Youth] | 0:5 | ||||
| 11. Round | 04/12/2021 | AC Milan [Youth] | - | SPAL 2013 Ferrara [Youth] | 4:1 | ||||
| 12. Round | 10/12/2021 | AS Roma [Youth] | - | SPAL 2013 Ferrara [Youth] | 4:1 | ||||
| 14. Round | 22/12/2021 | Atalanta [Youth] | - | SPAL 2013 Ferrara [Youth] | 3:0 |  |
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| 22. Round | 05/03/2022 | SPAL 2013 Ferrara [Youth] | - | Bologna FC [Youth] | 2:2 | ||||
| 23. Round | 09/03/2022 | Genoa CFC [Youth] | - | SPAL 2013 Ferrara [Youth] | 1:1 | ||||
| 24. Round | 13/03/2022 | SPAL 2013 Ferrara [Youth] | - | Delfino Pescara [Youth] | 1:2 | ||||
| 27. Round | 09/04/2022 | Sassuolo Calcio [Youth] | - | SPAL 2013 Ferrara [Youth] | 5:2 | ||||
| 29. Round | 16/04/2022 | SPAL 2013 Ferrara [Youth] | - | AS Roma [Youth] | 0:1 | ||||
| 32. Round | 29/04/2022 | Inter [Youth] | - | SPAL 2013 Ferrara [Youth] | 3:1 |
Italy