| 1. Round | 13/08/2022 | Sampdoria | - | Atalanta | 0:2 | ||||
| 2. Round | 22/08/2022 | Sampdoria | - | Juventus | 0:0 | ||||
| 3. Round | 28/08/2022 | US Salernitana 1919 | - | Sampdoria | 4:0 | ||||
| 4. Round | 31/08/2022 | Sampdoria | - | Lazio Roma | 1:1 | ||||
| 5. Round | 04/09/2022 | Hellas Verona | - | Sampdoria | 2:1 |  |
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| 6. Round | 10/09/2022 | Sampdoria | - | AC Milan | 1:2 | ||||
| 7. Round | 17/09/2022 | Spezia Calcio | - | Sampdoria | 2:1 | ||||
| 8. Round | 02/10/2022 | Sampdoria | - | AC Monza | 0:3 | ||||
| 9. Round | 08/10/2022 | Bologna FC | - | Sampdoria | 1:1 | ||||
| 10. Round | 17/10/2022 | Sampdoria | - | AS Roma | 0:1 | ||||
| 11. Round | 24/10/2022 | US Cremonese | - | Sampdoria | 0:1 | ||||
| 12. Round | 29/10/2022 | Inter | - | Sampdoria | 3:0 | ||||
| 13. Round | 06/11/2022 | Sampdoria | - | ACF Fiorentina | 0:2 | ||||
| 14. Round | 09/11/2022 | Torino FC | - | Sampdoria | 2:0 | ||||
| 15. Round | 12/11/2022 | Sampdoria | - | US Lecce | 0:2 |
Italy
