| 1. Round | 19/08/2022 | US Lecce [Youth] | - | SSC Napoli [Youth] | 2:0 | ||||
| 2. Round | 28/08/2022 | Frosinone Calcio [Youth] | - | US Lecce [Youth] | 0:2 | ||||
| 3. Round | 01/09/2022 | US Lecce [Youth] | - | Sampdoria [Youth] | 0:0 | ||||
| 4. Round | 05/09/2022 | Cesena FC [Youth] | - | US Lecce [Youth] | 1:0 | ||||
| 7. Round | 09/10/2022 | US Lecce [Youth] | - | Cagliari Calcio [Youth] | 0:1 | ||||
| 8. Round | 15/10/2022 | Empoli FC [Youth] | - | US Lecce [Youth] | 1:1 | ||||
| 9. Round | 23/10/2022 | US Lecce [Youth] | - | Bologna FC [Youth] | 0:1 | ||||
| 10. Round | 30/10/2022 | AS Roma [Youth] | - | US Lecce [Youth] | 1:0 |  |
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| 11. Round | 05/11/2022 | US Lecce [Youth] | - | Torino FC [Youth] | 2:3 | ||||
| 13. Round | 06/01/2023 | Juventus [Youth] | - | US Lecce [Youth] | 0:0 | ||||
| 19. Round | 15/02/2023 | US Lecce [Youth] | - | Frosinone Calcio [Youth] | 3:2 |
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