| 1. Round | 25/09/1960 | Torino FC | - | Sampdoria | 0:1 | ||||
| 2. Round | 02/10/1960 | Sampdoria | - | ACF Fiorentina | 3:1 | ||||
| 3. Round | 09/10/1960 | AC Lanerossi Vicenza | - | Sampdoria | 1:1 | ||||
| 12. Round | 25/12/1960 | Juventus | - | Sampdoria | 3:2 | ||||
| 13. Round | 01/01/1961 | Sampdoria | - | Calcio Padova | 3:0 | ||||
| 14. Round | 08/01/1961 | AS Roma | - | Sampdoria | 3:2 | ||||
| 15. Round | 15/01/1961 | Sampdoria | - | AS Bari | 1:0 | ||||
| 16. Round | 22/01/1961 | Udinese Calcio | - | Sampdoria | 7:1 | ||||
| 33. Round | 30/05/1961 | Sampdoria | - | Udinese Calcio | 3:2 | ||||
| 34. Round | 04/06/1961 | Bologna FC | - | Sampdoria | 4:4 |
Italy