| 15. Round | 29/01/2022 | Genoa CFC [Youth] | - | SSC Napoli [Youth] | 1:2 | ||||
| 16. Round | 01/02/2022 | Empoli FC [Youth] | - | Genoa CFC [Youth] | 0:1 | ||||
| 17. Round | 05/02/2022 | Genoa CFC [Youth] | - | AC Milan [Youth] | 0:0 | ||||
| 14. Round | 09/02/2022 | AS Roma [Youth] | - | Genoa CFC [Youth] | 1:0 | ||||
| 23. Round | 09/03/2022 | Genoa CFC [Youth] | - | SPAL 2013 Ferrara [Youth] | 1:1 | ||||
| 24. Round | 12/03/2022 | Bologna FC [Youth] | - | Genoa CFC [Youth] | 1:0 | ||||
| 19. Round | 16/03/2022 | Cagliari Calcio [Youth] | - | Genoa CFC [Youth] | 2:0 | ||||
| 25. Round | 20/03/2022 | Genoa CFC [Youth] | - | Juventus [Youth] | 1:2 | ||||
| 26. Round | 02/04/2022 | Sampdoria [Youth] | - | Genoa CFC [Youth] | 0:1 | ||||
| 27. Round | 10/04/2022 | Genoa CFC [Youth] | - | ACF Fiorentina [Youth] | 1:1 | ||||
| 28. Round | 13/04/2022 | Hellas Verona [Youth] | - | Genoa CFC [Youth] | 1:1 |  |
|||
| 29. Round | 16/04/2022 | Genoa CFC [Youth] | - | Inter [Youth] | 0:4 | ||||
| 31. Round | 24/04/2022 | Genoa CFC [Youth] | - | AS Roma [Youth] | 1:1 |  |
|||
| 34. Round | 15/05/2022 | AC Milan [Youth] | - | Genoa CFC [Youth] | 4:2 |
Italy