| 24. Round | 30/01/2022 | SS Monopoli 1966 | - | Virtus Francavilla | 0:0 |  |
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| 21. Round | 02/02/2022 | SS Monopoli 1966 | - | FC Turris | 2:1 |  |
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| 25. Round | 06/02/2022 | AZ Picerno | - | SS Monopoli 1966 | 3:0 | ||||
| 26. Round | 12/02/2022 | SS Monopoli 1966 | - | SSC Bari | 0:0 |  |
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| 28. Round | 19/02/2022 | SS Monopoli 1966 | - | Foggia Calcio | 0:1 | ||||
| 22. Round | 22/02/2022 | ACR Messina | - | SS Monopoli 1966 | 2:1 | ||||
| 29. Round | 26/02/2022 | Juve Stabia | - | SS Monopoli 1966 | 0:1 | |
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| 30. Round | 05/03/2022 | SS Monopoli 1966 | - | US Catanzaro | 2:1 | |
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| 31. Round | 13/03/2022 | Monterosi FC | - | SS Monopoli 1966 | 0:1 | |
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| 32. Round | 16/03/2022 | SS Monopoli 1966 | - | Vibonese Calcio | 3:0 | |
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| 34. Round | 27/03/2022 | SS Monopoli 1966 | - | Potenza | 3:1 | |
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| 35. Round | 02/04/2022 | Paganese Calcio | - | SS Monopoli 1966 | 0:1 | ||||
| 33. Round | 06/04/2022 | Taranto FC | - | SS Monopoli 1966 | 2:0 | ||||
| 36. Round | 09/04/2022 | SS Monopoli 1966 | - | Palermo FC | 0:2 | ||||
| 37. Round | 16/04/2022 | Latina Calcio | - | SS Monopoli 1966 | 0:0 | ||||
| 38. Round | 24/04/2022 | SS Monopoli 1966 | - | Fidelis Andria | 2:1 | |
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