| 1. Round | 25/09/1960 | AC Lanerossi Vicenza | - | SSC Napoli | 2:3 | ||||
| 2. Round | 02/10/1960 | SSC Napoli | - | Torino FC | 1:1 | ||||
| 3. Round | 09/10/1960 | Lazio Roma | - | SSC Napoli | 1:1 | ||||
| 4. Round | 16/10/1960 | Bologna FC | - | SSC Napoli | 0:2 | ||||
| 5. Round | 23/10/1960 | SSC Napoli | - | AS Roma | 3:2 | ||||
| 6. Round | 06/11/1960 | SPAL Ferrara | - | SSC Napoli | 3:2 | ||||
| 13. Round | 01/01/1961 | Udinese Calcio | - | SSC Napoli | 1:1 | ||||
| 14. Round | 08/01/1961 | SSC Napoli | - | Calcio Catania | 0:1 | ||||
| 24. Round | 19/03/1961 | ACF Fiorentina | - | SSC Napoli | 0:0 | ||||
| 25. Round | 26/03/1961 | SSC Napoli | - | Sampdoria | 1:0 | ||||
| 26. Round | 02/04/1961 | AC Milan | - | SSC Napoli | 2:1 | ||||
| 27. Round | 09/04/1961 | SSC Napoli | - | Calcio Lecco 1912 | 3:1 | ||||
| 28. Round | 16/04/1961 | AS Bari | - | SSC Napoli | 1:0 | ||||
| 29. Round | 30/04/1961 | Atalanta | - | SSC Napoli | 1:1 | ||||
| 31. Round | 14/05/1961 | Calcio Catania | - | SSC Napoli | 1:0 | ||||
| 32. Round | 21/05/1961 | SSC Napoli | - | Juventus | 0:4 | ||||
| 33. Round | 30/05/1961 | Inter | - | SSC Napoli | 3:0 |  |
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