| 6. Round | 22/10/2021 | SPAL 2013 Ferrara [Youth] | - | Genoa CFC [Youth] | 1:3 | ||||
| 10. Round | 28/11/2021 | ACF Fiorentina [Youth] | - | Genoa CFC [Youth] | 0:0 | ||||
| 12. Round | 11/12/2021 | Inter [Youth] | - | Genoa CFC [Youth] | 2:2 |  |
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| 15. Round | 29/01/2022 | Genoa CFC [Youth] | - | SSC Napoli [Youth] | 1:2 | ||||
| 23. Round | 09/03/2022 | Genoa CFC [Youth] | - | SPAL 2013 Ferrara [Youth] | 1:1 | ||||
| 24. Round | 12/03/2022 | Bologna FC [Youth] | - | Genoa CFC [Youth] | 1:0 |  |
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| 19. Round | 16/03/2022 | Cagliari Calcio [Youth] | - | Genoa CFC [Youth] | 2:0 | ||||
| 25. Round | 20/03/2022 | Genoa CFC [Youth] | - | Juventus [Youth] | 1:2 | ||||
| 32. Round | 30/04/2022 | SSC Napoli [Youth] | - | Genoa CFC [Youth] | 1:1 | |
Italy