| 3. Round | 09/10/1960 | AC Lanerossi Vicenza | - | Sampdoria | 1:1 | ||||
| 4. Round | 16/10/1960 | Sampdoria | - | AC Milan | 2:2 | ||||
| 5. Round | 23/10/1960 | SPAL Ferrara | - | Sampdoria | 2:2 | ||||
| 6. Round | 06/11/1960 | Sampdoria | - | Lazio Roma | 1:0 | ||||
| 7. Round | 13/11/1960 | Calcio Lecco 1912 | - | Sampdoria | 1:1 | ||||
| 12. Round | 25/12/1960 | Juventus | - | Sampdoria | 3:2 | ||||
| 15. Round | 15/01/1961 | Sampdoria | - | AS Bari | 1:0 | ||||
| 21. Round | 26/02/1961 | AC Milan | - | Sampdoria | 3:1 |
Italy