| Group C | 16/09/2021 | Leicester City | - | SSC Napoli | 2:2 |  |
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| Group C | 30/09/2021 | SSC Napoli | - | Spartak Moskva | 2:3 | |
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| Group C | 21/10/2021 | SSC Napoli | - | Legia Warszawa | 3:0 | ||||
| Group C | 04/11/2021 | Legia Warszawa | - | SSC Napoli | 1:4 | ||||
| Group C | 24/11/2021 | Spartak Moskva | - | SSC Napoli | 2:1 | ||||
| Group C | 09/12/2021 | SSC Napoli | - | Leicester City | 3:2 | ||||
| Play-offs | 17/02/2022 | FC Barcelona | - | SSC Napoli | 1:1 | ||||
| Play-offs | 24/02/2022 | SSC Napoli | - | FC Barcelona | 2:4 |
Italy
