| 1. Round | 28/08/2010 | Udinese Calcio | - | Genoa CFC | 0:1 |  |
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| 2. Round | 12/09/2010 | Genoa CFC | - | Chievo Verona | 1:3 | ||||
| 3. Round | 19/09/2010 | Parma FC | - | Genoa CFC | 1:1 | |
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| 4. Round | 22/09/2010 | Genoa CFC | - | ACF Fiorentina | 1:1 | |
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| 5. Round | 25/09/2010 | AC Milan | - | Genoa CFC | 1:0 | |
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| 7. Round | 16/10/2010 | AS Roma | - | Genoa CFC | 2:1 | ||||
| 19. Round | 09/01/2011 | AC Cesena | - | Genoa CFC | 0:0 | ||||
| 20. Round | 16/01/2011 | Genoa CFC | - | Udinese Calcio | 2:4 |
Italy
