Round of 16 | 08/04/2021 | Olimpia | - | CF América | 1:2 | ||||
Round of 16 | 15/04/2021 | CF América | - | Olimpia | 0:1 | ||||
Quarter-finals | 29/04/2021 | Portland Timbers | - | CF América | 1:1 | ||||
Quarter-finals | 06/05/2021 | CF América | - | Portland Timbers | 3:1 | ||||
Semi-finals | 13/08/2021 | CF América | - | Philadelphia Union | 2:0 | ||||
Semi-finals | 16/09/2021 | Philadelphia Union | - | CF América | 0:2 | ||||
Final | 29/10/2021 | CF Monterrey | - | CF América | 1:0 |