| 1. Round | 08/08/2021 | OGC Nice | - | Stade de Reims | 0:0 | ||||
| 2. Round | 14/08/2021 | Lille OSC | - | OGC Nice | 0:4 | ||||
| 4. Round | 28/08/2021 | OGC Nice | - | Girondins Bordeaux | 4:0 | ||||
| 5. Round | 12/09/2021 | FC Nantes | - | OGC Nice | 0:2 | ||||
| 8. Round | 25/09/2021 | AS Saint-Étienne | - | OGC Nice | 0:3 |  |
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| 9. Round | 02/10/2021 | OGC Nice | - | Stade Brestois 29 | 2:1 | ||||
| 10. Round | 17/10/2021 | ESTAC Troyes | - | OGC Nice | 1:0 | ||||
| 3. Round | 27/10/2021 | OGC Nice | - | Olympique Marseille | 1:1 | ||||
| 12. Round | 31/10/2021 | Angers SCO | - | OGC Nice | 1:2 | |
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| 13. Round | 07/11/2021 | OGC Nice | - | Montpellier HSC | 0:1 | ||||
| 14. Round | 21/11/2021 | Clermont Foot 63 | - | OGC Nice | 1:2 |
France
