1. Round | 11/09/2021 | Panetolikos | - | Asteras Tripolis | 0:0 | ||||
2. Round | 19/09/2021 | Atromitos | - | Panetolikos | 1:2 | ||||
3. Round | 22/09/2021 | Panetolikos | - | PAOK Saloniki | 1:2 | ||||
4. Round | 26/09/2021 | Lamia | - | Panetolikos | 2:2 | ||||
5. Round | 03/10/2021 | Panetolikos | - | AEK Athen | 1:3 | ||||
6. Round | 17/10/2021 | Panetolikos | - | OFI Heraklion | 1:2 | ||||
7. Round | 24/10/2021 | Aris Saloniki | - | Panetolikos | 5:1 |