| 5. Round | 18/09/2021 | Willem II | - | FC Groningen | 2:1 | ||||
| 8. Round | 02/10/2021 | Heracles Almelo | - | Willem II | 3:2 | ||||
| 12. Round | 06/11/2021 | Willem II | - | Sparta Rotterdam | 0:3 | ||||
| 13. Round | 21/11/2021 | sc Heerenveen | - | Willem II | 2:1 | ||||
| 14. Round | 27/11/2021 | Willem II | - | Go Ahead Eagles | 0:1 | ||||
| 15. Round | 02/12/2021 | AFC Ajax | - | Willem II | 5:0 |  |
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| 16. Round | 10/12/2021 | Willem II | - | SC Cambuur | 1:3 | ||||
| 18. Round | 22/12/2021 | Willem II | - | NEC Nijmegen | 0:1 |
Germany