1. Round | 12/09/2021 | PAOK Saloniki | - | PAS Giannina | 0:1 | ||||
2. Round | 19/09/2021 | Asteras Tripolis | - | PAOK Saloniki | 0:1 | ||||
3. Round | 22/09/2021 | Panetolikos | - | PAOK Saloniki | 1:2 | ||||
4. Round | 26/09/2021 | PAOK Saloniki | - | AEK Athen | 2:0 | ||||
5. Round | 03/10/2021 | OFI Heraklion | - | PAOK Saloniki | 1:3 | ||||
6. Round | 17/10/2021 | PAOK Saloniki | - | Volos NFC | 4:4 | ||||
7. Round | 24/10/2021 | Olympiakos Piraeus | - | PAOK Saloniki | 2:1 | ||||
8. Round | 30/10/2021 | PAOK Saloniki | - | Apollon Smyrnis | 4:1 | ||||
9. Round | 07/11/2021 | Panathinaikos | - | PAOK Saloniki | 1:3 | ||||
10. Round | 21/11/2021 | Atromitos | - | PAOK Saloniki | 2:0 | ||||
11. Round | 28/11/2021 | PAOK Saloniki | - | Aris Saloniki | 0:1 | ||||
12. Round | 05/12/2021 | Ionikos Nikea | - | PAOK Saloniki | 3:2 | ||||
13. Round | 12/12/2021 | PAOK Saloniki | - | Lamia | 2:1 | ||||
15. Round | 19/12/2021 | PAOK Saloniki | - | Asteras Tripolis | 3:2 | ||||
16. Round | 12/01/2022 | PAOK Saloniki | - | Panetolikos | 2:0 | ||||
18. Round | 15/01/2022 | PAOK Saloniki | - | OFI Heraklion | 3:0 |