| 15. Round | 06/01/2008 | Atromitos | - | Panionios GSS | 0:2 | ||||
| 18. Round | 27/01/2008 | Panionios GSS | - | Apollon Kalamarias | 2:1 | ||||
| 19. Round | 03/02/2008 | AEK Athen | - | Panionios GSS | 2:3 |  |
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| 20. Round | 10/02/2008 | Panionios GSS | - | Olympiakos Piraeus | 0:4 | ||||
| 21. Round | 16/02/2008 | AE Lárissa | - | Panionios GSS | 1:0 | ||||
| 22. Round | 24/02/2008 | Panionios GSS | - | Ergotelis | 2:1 | |
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| 23. Round | 02/03/2008 | Skoda Xanthi | - | Panionios GSS | 1:2 | |
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| 24. Round | 08/03/2008 | Panionios GSS | - | PAOK Saloniki | 0:0 | ||||
| 25. Round | 16/03/2008 | Iraklis Saloniki | - | Panionios GSS | 1:0 | ||||
| 26. Round | 23/03/2008 | Panionios GSS | - | Asteras Tripolis | 4:1 | |
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| 27. Round | 30/03/2008 | Panathinaikos | - | Panionios GSS | 2:1 | |
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| 28. Round | 06/04/2008 | Panionios GSS | - | Veria FC | 2:2 | ||||
| 29. Round | 13/04/2008 | OFI Heraklion | - | Panionios GSS | 1:2 | |
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| 30. Round | 20/04/2008 | Panionios GSS | - | Atromitos | 2:1 | |
Greece