| 2. Round | 14/08/2022 | AFC Ajax | - | FC Groningen | 6:1 | ||||
| 7. Round | 18/09/2022 | AZ Alkmaar | - | AFC Ajax | 2:1 | ||||
| 8. Round | 01/10/2022 | AFC Ajax | - | Go Ahead Eagles | 1:1 |  |
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| 10. Round | 16/10/2022 | AFC Ajax | - | SBV Excelsior | 7:1 | ||||
| 11. Round | 22/10/2022 | RKC Waalwijk | - | AFC Ajax | 1:4 | ||||
| 13. Round | 06/11/2022 | AFC Ajax | - | PSV Eindhoven | 1:2 |  |
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| 12. Round | 09/11/2022 | AFC Ajax | - | Vitesse | 2:2 | |
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| 14. Round | 12/11/2022 | FC Emmen | - | AFC Ajax | 3:3 | ||||
| 15. Round | 08/01/2023 | NEC Nijmegen | - | AFC Ajax | 1:1 | ||||
| 18. Round | 26/01/2023 | AFC Ajax | - | FC Volendam | 1:1 | ||||
| 26. Round | 19/03/2023 | AFC Ajax | - | Feyenoord | 2:3 | ||||
| 27. Round | 02/04/2023 | Go Ahead Eagles | - | AFC Ajax | 0:0 | ||||
| 30. Round | 23/04/2023 | PSV Eindhoven | - | AFC Ajax | 3:0 | ||||
| 34. Round | 28/05/2023 | FC Twente | - | AFC Ajax | 3:1 |
Italy