| 4. Round | 05/09/2022 | Sampdoria [Youth] | - | Sassuolo Calcio [Youth] | 1:1 | ||||
| 5. Round | 12/09/2022 | Atalanta [Youth] | - | Sampdoria [Youth] | 2:1 | ||||
| 6. Round | 01/10/2022 | Sampdoria [Youth] | - | Frosinone Calcio [Youth] | 1:2 | ||||
| 10. Round | 29/10/2022 | Empoli FC [Youth] | - | Sampdoria [Youth] | 0:0 | ||||
| 11. Round | 04/11/2022 | Sampdoria [Youth] | - | Bologna FC [Youth] | 2:3 |  |
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| 13. Round | 07/01/2023 | Sampdoria [Youth] | - | Cesena FC [Youth] | 4:2 |  |
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| 14. Round | 15/01/2023 | Torino FC [Youth] | - | Sampdoria [Youth] | 2:0 | ||||
| 15. Round | 20/01/2023 | Sampdoria [Youth] | - | Inter [Youth] | 2:1 | |
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| 16. Round | 29/01/2023 | ACF Fiorentina [Youth] | - | Sampdoria [Youth] | 0:1 | |
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| 18. Round | 11/02/2023 | Hellas Verona [Youth] | - | Sampdoria [Youth] | 1:5 | |
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| 19. Round | 15/02/2023 | AC Milan [Youth] | - | Sampdoria [Youth] | 1:1 | ||||
| 20. Round | 19/02/2023 | Sampdoria [Youth] | - | US Lecce [Youth] | 1:2 | |
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| 25. Round | 01/04/2023 | Sampdoria [Youth] | - | Cagliari Calcio [Youth] | 1:1 | ||||
| 32. Round | 17/05/2023 | Inter [Youth] | - | Sampdoria [Youth] | 2:1 | |
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| 33. Round | 22/05/2023 | Sampdoria [Youth] | - | ACF Fiorentina [Youth] | 1:2 | |
Italy