| 1. Round | 20/09/1959 | AS Roma | - | Genoa CFC | 1:0 | ||||
| 2. Round | 27/09/1959 | Genoa CFC | - | Bologna FC | 0:2 | ||||
| 3. Round | 04/10/1959 | SSC Napoli | - | Genoa CFC | 0:2 dec. | ||||
| 4. Round | 11/10/1959 | AS Bari | - | Genoa CFC | 1:0 | ||||
| 5. Round | 18/10/1959 | Genoa CFC | - | AC Milan | 0:2 | ||||
| 6. Round | 25/10/1959 | Genoa CFC | - | AC Lanerossi Vicenza | 0:2 | ||||
| 10. Round | 06/12/1959 | Genoa CFC | - | Atalanta | 1:1 | ||||
| 16. Round | 24/01/1960 | US Palermo | - | Genoa CFC | 1:1 | ||||
| 26. Round | 10/04/1960 | Genoa CFC | - | Juventus | 2:6 | ||||
| 27. Round | 17/04/1960 | Atalanta | - | Genoa CFC | 2:1 | ||||
| 28. Round | 24/04/1960 | Genoa CFC | - | Calcio Padova | 0:0 | ||||
| 31. Round | 15/05/1960 | SPAL Ferrara | - | Genoa CFC | 0:0 | ||||
| 32. Round | 22/05/1960 | Genoa CFC | - | Lazio Roma | 2:4 | ||||
| 34. Round | 05/06/1960 | ACF Fiorentina | - | Genoa CFC | 2:0 |
Italy